Nicoclear is a topical gel for treating acne, containing clindamycin (an antibiotic) and nicotinamide (a form of Vitamin B3). Its benefits include reducing sebum (oil) production, killing acne-causing bacteria, reducing inflammation, and preventing new breakouts and scars. To use it, apply a thin layer to the affected area as directed by a doctor, avoiding the eyes and mucous membranes. Common side effects can include skin dryness, redness, peeling, or irritation, which usually disappear as the body adjusts to the medication.