Tretin-0.05% is a topical cream containing tretinoin, a vitamin A derivative, used to treat acne, improve skin texture, and reduce wrinkles by promoting skin cell turnover and decreasing oil production. Its benefits include unclogging pores, reducing blackheads and pimples, and smoothing rough skin, though initial dryness and irritation can occur. Proper use involves applying a thin layer at night after cleaning and drying the skin, avoiding sun exposure, and using moisturizer to combat dryness.